FOXP2 and language alterations in psychiatric pathology
نویسندگان
چکیده
منابع مشابه
FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder.
Disruption of FOXP2, a gene encoding a forkhead-domain transcription factor, causes a severe developmental disorder of verbal communication, involving profound articulation deficits, accompanied by linguistic and grammatical impairments. Investigation of the neural basis of this disorder has been limited previously to neuroimaging of affected children and adults. The discovery of the gene respo...
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Rare mutations of the FOXP2 transcription factor gene cause a monogenic syndrome characterized by impaired speech development and linguistic deficits. Recent genomic investigations indicate that its downstream neural targets make broader impacts on common language impairments, bridging clinically distinct disorders. Moreover, the striking conservation of both FoxP2 sequence and neural expressio...
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Devanna et al. (2014) have demonstrated that FOXP2 mimics, and actually potentiates, retinoic acid (RA) induction of genes involved in neural differentiation. At the physiological level this effect results in an increase of neurite outgrowth and branching, and in a reduction of neuronal migration. The authors highlight the importance of RA signaling for brain growth and differentiation, and the...
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ژورنال
عنوان ژورنال: Salud mental
سال: 2019
ISSN: 0185-3325
DOI: 10.17711/sm.0185-3325.2019.039